Aktivitas Antikanker Nanokapsul Ekstrak Mengkudu (Morinda citrifolia L.) dengan Pengujian in Vivo pada Fibrosarkoma Mencit Jantan Balb/c
(In Vivo Anticancer Activity of Nanoencapsulated Noni (Morinda citrifolia L) Extract on Fibrosarcoma of Balb/c Male Mice)
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Nur Aisyah
Program Studi Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian, Universitas Jember, Indonesia
Lulus Kartika Ningtias
Program Studi Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian, Universitas Jember, Indonesia
Ancah Caesarina Novi Marchianti
Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Jember, Indonesia
Bambang Piluharto
Jurusan Kimia, Fakultas Matematika dan Ilmu Pendidikan Alam, Universitas Jember, Indonesia
Deltaningtyas Tri Cahyaningrum
Program Studi Manajemen Agroindustri, Politeknik Negeri Jember, Indonesia
Naning Retnowati
Program Studi Manajemen Agroindustri, Politeknik Negeri Jember, Indonesia
Nurud Diniyah
Program Studi Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian, Universitas Jember, Indonesia
Iswahyono
Program Studi Keteknikan Pertanian, Politeknik Negeri Jember, Indonesia
Riska Rian Fauziah
Program Studi Teknologi Hasil Pertanian, Fakultas Teknologi Pertanian, Universitas Jember, Indonesia
DOI: https://doi.org/10.19184/j-agt.v16i02.31182
ABSTRACT
Noni (Morinda citrifolia L.) is one of the many herbs which known as anticancer agent. Nanoencapsulated form of noni extracts could help the body absorption and able to inhibit the proliferation of cancer cells in vitro. This study was conducted to examine the anticancer activity of nanoencapsulated noni extracts in vivo as the anti-proliferation agent of cancer cells. Noni extract was obtained by maceration method using water as a solvent. The nanocapsule of noni extracts was made using ionic gelation method by magnetic stirrer with speed of 1500 rpm. In vivo anticancer activity test was conducted in Balb/c male mice by comparing the treatment of nanoencapsulated noni extracts and non encapsulated extracts. The result showed that the nanoencapsulated noni extracts has a particle size of 27-59 nm. Percent of inhibition of nanocapsule on cancer cells (specifically on fibrosarcoma of Balb/c male mice) were equal to 54.75% (P2), while non-encapsulated is 49.72% (P1). Nanocapsule of noni extracts has anticancer activity better than non-encapsulated form on fibrosarcoma of Balb/c male mice.
Keywords: anticancer, nanoencapsulation, noni extract
REFERENCES
Chuan, L., Jia, Z., Jiao, Z.Y., Fang, N.S., Jun, C., Qian, W., Ping, N.S., Yuan, D.Z., & Shu, W. (2017). Biocompatible and biodegradable nanoparticles for enhancement of anti-cancer activities of phytochemicals. China Journal of Natural Medicine, 13(9), 641–652. DOI: 10.1016/S1875-5364(15)30061-3
Citrawani, E. (2012). "Antiprolifersi Sel Kanker dan Karakterisasi Nanokapsul Ekstrak Mengkudu (Morinda citrifolia L)". Skripsi. Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor.
Ferlay, J., Ervik, M., Lam, F., Colombet, M., Mery, L., & Piñeros, M. (2021). Cancer statistics for the year 2020: An overview. International Journal of Cancer, pp. 1–12. DOI: 10.1002/ijc.33588
Hartig, S.M., Greene, R.R., DasGupta, J., & Carlesso, C. (2007). Multifunction nanoparticulate polyelectrolyte complexe. Pharmaceutical Resources, 24(12), 2353–2369. DOI: 10.1007/s11095-007-9459-1
Hiraizumi, A., & Furusawa, E. (1999). An immune-modulatory polysaccharide-rich substance from the fruit juice of Morinda citrifolia (noni) with antitumor activity. Phytotherapy Resources, 13(5), 380–387. DOI: 10.1002/(sici)1099-1573(199908/09)13:5<380::aid-ptr463>3.0.co;2-m
Kencana, R. (2009). "Perlakuan Sonikasi Terhadap Kitosan Viskositas dan Bobot Molekul". Skripsi. Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Bogor.
Kim, D.G. (2006). Retinol-encapsulated low molecular water-soluble chitosan nanoparticles. International Journal of Pharmaceutics, 319(1-2), 130–138. DOI: 10.1016/j.ijpharm.2006.03.040
Lucas, J., Ralaivo, M., Estevinho, B.N., & Rocha, F. (2020). A new approach for the microencapsulation of curcumin by a spray drying method, in order to value food products. Powder Technology, 362, 428–435. DOI: 10.1016/j.powtec.2019.11.095
Mohanraj, V.J. (2006). Nanoparticles - A review. Tropical Journal of Pharmaceutical Research, 5(1), 561–573. DOI: 10.4314/tjpr.v5i1.14634
Nelson, W. (2006). Morinda citrifolia (Noni). Species Profiles for Pasific Island Agroforestry. [terhubung berkala]. (www. traditional.org). [Diakses tanggal 10 September 2014].
Nugroho, K.D. (2020). Studi fenomenologi: Pengabaian gejala awal kanker mengakibatkan respon negatif bagi klien dan keluarga. Jurnal Keperawatan Malang, 5(1), 46–54. https://doi.org/10.36916/jkm.v5i1.105
Pohan, H.G., & Antara, N.T. (2011). Pengaruh penambahan madu dan asam sitrat terhadap karakteristik minuman fungsional dari sari buah mengkudu. Forum Komunikasi IHP, 4, 11–20.
Rohman, L. (2006). Aktivitas antioksidan, kandungan fenolik total ekstrak etil asetat buah mengkudu serta fraksi-fraksinya. Majalah Farmasi Indonesia, 17, 136–142.
Schreiber, D. (2007). Hidup bebas kanker. Rani Ekawati, penerjemah. Bandung: Mizan Media Utama. Terjemahan dari: Anticancer: A New Way of Life.
Smeltzer, S.C. (1996). Buku ajar keperawatan Medikal-bedah Brunner & Suddarth. Vol. 1 Edisi 8. Alih Bahasa oleh Agung Waluyo dkk 2001. Jakarta: EGC Press.
Solomon, N. (1998). Noni. Nature’s amazing healer. Woodland Publ. Pleasant Grove, Utah, USA.
Sugita, S. (2006). "Pengaruh Kadar PEG 600 Terhadap Mutu Fisik Tablet Ekstrak Mengkudu dalam Dispersi Padat Ekstrak Mengkudu PEG 600 yang Dibuat secara Cetak Langsung". Skripsi. Fakultas Farmasi, Universitas Airlangga, Surabaya.
Sung, H., Ferlay, J., Siegel, R.L., Lavarsanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 71, 209–249. DOI: 10.3322/caac.21660
Taskin, E.I., Dar, K.A., Kapucu, A., Osanc, E., Dogruman, H., Eraltan, H., & Ulukaya, E. (2009). Apoptosis-inducing effect of Morinda citrifolia and doxorubicin on the ehrlich ascites tumor in BALB-c mice. Cell Biochemical Function, 27(8), 542–546. DOI: 10.1002/cbf.1604
Wang, M.Y., Brest, B.J., Jensen, C.J., Nowicki, D., Su, C., Palu, A.K., & Andersen, G. (2002). Morinda citrifolia (noni): A literature review and recent advances in noni research. Acta Pharmacology, 23(12), 1.127–1.141. https://doi.org/10.1016/j.arabjc.2015.06.018
Waha, M.G. (2001). Sehat dengan mengkudu. Jakarta: MSF Group.
Published
20-12-2022
Issue
Vol. 16 No. 2 2022: Jurnal Agroteknologi
Pages
112-120
License
Copyright (c) 2022 Jurnal Agroteknologi
How to Cite
Aisyah, N., Ningtias, L.K., Marchianti, A.C.N., Piluharto, B., Cahyaningrum, D.T., Retnowati, N., Diniyah, N., Iswahyono, & Fauziah, R.R. (2022). Aktivitas antikanker nanokapsul ekstrak mengkudu (Morinda citrifolia L.) dengan pengujian in vivo pada fibrosarkoma mencit jantan Balb/c. Jurnal Agroteknologi, 16(2), 112-120. https://doi.org/10.19184/j-agt.v16i02.31182
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